接受美沙酮和醋美沙朵治疗患者的染色体。

Chromosomes in patients receiving methadone and methadyl acetate.

作者信息

Matsuyama S S, Charuvastra V C, Jarvik L F, Fu T K, Sanders K, Yen F S

出版信息

Arch Gen Psychiatry. 1978 Aug;35(8):989-91. doi: 10.1001/archpsyc.1978.01770320083007.

DOI:10.1001/archpsyc.1978.01770320083007

Abstract

Chromosomes of peripheral leukocytes were examined in 28 addicts participating in a Veterans Administration-Special Action Office for Drug Abuse Prevention (SAODAP) cooperative study of methadyl acetate vs methadone. Blood samples for 72-hour leukocyte cultures were drawn after nearly 40 weeks of maintenance therapy while subjects were receiving active medication. For comparison, ten nondrug users were also studied. The frequency of chromosome damage was not greater in subjects maintained on methadyl acetate or methadone than in nondrug users.

摘要

在一项由退伍军人管理局 - 预防药物滥用特别行动办公室（SAODAP）开展的关于醋美沙朵与美沙酮对比的合作研究中，对28名成瘾者的外周血白细胞染色体进行了检查。在维持治疗近40周后，当受试者正在接受活性药物治疗时，采集用于72小时白细胞培养的血样。作为对照，还对10名非药物使用者进行了研究。接受醋美沙朵或美沙酮维持治疗的受试者的染色体损伤频率并不高于非药物使用者。