Heber D, Swerdloff R S
J Clin Endocrinol Metab. 1981 Feb;52(2):171-2. doi: 10.1210/jcem-52-2-171.
Four normal postmenopausal females were infused with synthetic gonadotropin-releasing hormone (GnRH) iv at a rate of 1 microgram/min for 72 h. Serum LH, FSH, and estradiol were measured every 4 h. LH and FSH levels increased from basal values of 23 +/- 3 and 94 +/- 27 mIU/ml, respectively, to peak values of 50 +/- 5 and 145 +/- 9 mIU/ml at 12 h. Serum LH then fell progressively toward basal levels during the continued iv administration of GnRH. Serum FSH fell below basal levels and remained suppressed between 36-72 h of the study period. Serum estradiol remained at levels less than 25 pg/ml throughout the GnRH infusion. Studies of LH and FSH secretion during the continuous administration of GnRH may be a useful model with which to study paradoxical down-regulation of pituitary gonadotropin secretion.
对4名绝经后正常女性静脉注射合成促性腺激素释放激素（GnRH），速率为1微克/分钟，持续72小时。每4小时测量血清促黄体生成素（LH）、促卵泡生成素（FSH）和雌二醇水平。LH和FSH水平分别从基础值23±3和94±27 mIU/ml，在12小时时升至峰值50±5和145±9 mIU/ml。在持续静脉注射GnRH期间，血清LH随后逐渐降至基础水平。血清FSH降至基础水平以下，并在研究期的36 - 72小时内持续受到抑制。在GnRH输注过程中，血清雌二醇水平始终低于25 pg/ml。持续注射GnRH期间对LH和FSH分泌的研究可能是研究垂体促性腺激素分泌反常下调的有用模型。
