Ropert J F, Quigley M E, Yen S S
J Clin Endocrinol Metab. 1981 Mar;52(3):583-5. doi: 10.1210/jcem-52-3-583.
To test the postulate that endogenous opioid peptides may be involved in the neuroendocrine mechanisms controlling the frequency and amplitude of LH pulses, saline and an opioid receptor antagonist, naloxone, were infused sequentially, each for 6-h intervals, in six normal cycling women during the luteal phase of the menstrual cycle. During naloxone infusion (1.6 mg/h), there was a significant (P less than 0.01) increase in both the frequency and amplitude of LH pulses compared to those in saline controls. FSH pulses were not discernible in individual subjects; however, a significant increment in FSH levels occurred concomitantly with the increase in LH. These data strongly suggest that endogenous opiates, through an inhibition of hypothalamic LRF, participate in the endocrine events leading to the low frequency of episodic LH secretion characteristic of the luteal phase of the human menstrual cycle.
为了验证内源性阿片肽可能参与控制促黄体生成素（LH）脉冲频率和幅度的神经内分泌机制这一假设，在月经周期的黄体期，对6名正常月经周期的女性依次输注生理盐水和一种阿片受体拮抗剂纳洛酮，每次输注间隔6小时。在输注纳洛酮期间（1.6毫克/小时），与生理盐水对照组相比，LH脉冲的频率和幅度均显著增加（P<0.01）。在个体受试者中无法辨别促卵泡生成素（FSH）脉冲；然而，FSH水平的显著升高与LH的升高同时发生。这些数据强烈表明，内源性阿片类物质通过抑制下丘脑促性腺激素释放因子（LRF），参与了导致人类月经周期黄体期特征性的LH分泌频率较低的内分泌事件。
