Karl H J
MMW Munch Med Wochenschr. 1980 Aug 29;122(35):1191-4.
In reviewing the unwanted effects and side-effects of corticosteroid therapy, the principle guidelines for their use and contraindications are dealt with. Then the effects of a pharmacodynamic therapy on the metabolism of carbohydrates, proteins and fat and also the mineral balance are discussed and e.g. steroid diabetes, osteoporosis and myopathies are gone into. At the same time, the special properties of the various synthetic derivatives of cortisol, cortisone and corticosterone are referred to. Besides undesirable complications of corticosteroids in the gastrointestinal region, blood clotting and the influence on the course of infections and the psychic behavior, the side-effects on the skin and eyes are discussed. In closing, suggestions on the general measures of supervision and information of the patient are given. The principle of therapeutic decision is finally benefit: assessment of the risk to each patient.
在回顾皮质类固醇疗法的不良反应和副作用时，阐述了其使用的主要指南和禁忌证。接着讨论了药效学疗法对碳水化合物、蛋白质和脂肪代谢以及矿物质平衡的影响，例如类固醇糖尿病、骨质疏松症和肌病。同时，提及了皮质醇、可的松和皮质酮各种合成衍生物的特殊性质。除了皮质类固醇在胃肠道区域、血液凝固方面的不良并发症以及对感染病程和精神行为的影响外，还讨论了对皮肤和眼睛的副作用。最后，给出了关于对患者进行总体监测和告知的建议。治疗决策的原则最终是获益：评估每位患者的风险。
