Fang V S, Shian L R
Endocrinology. 1981 Apr;108(4):1545-51. doi: 10.1210/endo-108-4-1545.
Basel plasma levels and pituitary content of TSH and PRL were measured in young male rats after bilateral adrenalectomy with and without corticosterone replacement. Adrenal ablation for a period of 4 days resulted in the arrest of body weight gain, a remarkable hemoconcentration, the slight and insignificant increase in plasma TSH and PRL, but no significant changes in the pituitary content of TSH and PRL and the hypothalamic content of catecholamines, as compared with the control animals. Adequate glucocorticoid replacement in adrenalectomized rats, as determined by the plasma level of corticosterone, did not result in a comparable weight gain, as in the control group, but did reduce plasma protein to almost normal levels. The plasma levels of TSH and PRL in the adrenalectomized animals were significantly suppressed, although the pituitary contents of TSH and PRL were not different from the control values. Four days after adrenalectomy, pituitary stimulation tests with TRH, chlorpromazine, and metoclopramide produced much higher levels of plasma TSH and PRL in the adrenalectomized rats than in the control group. Replacement of corticosterone in the adrenalectomized rats diminished the excess of TSH and PRL responsiveness. These results suggest that adrenal glands may not be directly involved in the hypothalamic control of the pituitary content of TSH and PRL, as they are in the case of ACTH. However, physiological levels of glucocorticoids clearly exert an inhibitory effect on TSH and PRL release by the pituitary gland in response to provocative stimulation.
在年轻雄性大鼠双侧肾上腺切除术后，测定了有无皮质酮替代情况下的促甲状腺激素（TSH）和催乳素（PRL）的巴塞尔血浆水平以及垂体含量。肾上腺切除4天导致体重增加停止、显著的血液浓缩、血浆TSH和PRL略有增加但不显著，与对照动物相比，垂体中TSH和PRL的含量以及下丘脑儿茶酚胺的含量无显著变化。通过皮质酮血浆水平确定，在肾上腺切除的大鼠中给予足够的糖皮质激素替代，并未导致与对照组相当的体重增加，但确实使血浆蛋白降至几乎正常水平。肾上腺切除动物的血浆TSH和PRL水平显著降低，尽管垂体中TSH和PRL的含量与对照值无差异。肾上腺切除4天后，用促甲状腺激素释放激素（TRH）、氯丙嗪和甲氧氯普胺进行垂体刺激试验，肾上腺切除大鼠的血浆TSH和PRL水平比对照组高得多。肾上腺切除大鼠中皮质酮的替代减少了TSH和PRL反应性的过度增强。这些结果表明，肾上腺可能不像在促肾上腺皮质激素（ACTH）的情况那样直接参与下丘脑对垂体中TSH和PRL含量的控制。然而，糖皮质激素的生理水平明显对垂体在受到刺激时释放TSH和PRL发挥抑制作用。
