Dussault J H
Can Med Assoc J. 1974 Dec 7;111(11):1195-7.
Serum thyrotropin (TSH) and prolactin levels were measured after intravenous administration of 400 mug of synthetic thyrotropin-releasing hormone (TRH) in 13 normal subjects and six hypothyroid patients before and after three days of administration of dexamethasone 2 mg per day. In the normal subjects dexamethasone suppressed baseline serum levels and secretion of TSH after TRH stimulation. On the other hand, it had no effect on the hypothyroid patients. In the control group dexamethasone also suppressed baseline serum levels but not secretion of prolactin after TRH stimulation. Dexamethasone had no effect on prolactin levels in the hypothyroid group. It is concluded that in normal patients short-term administration of dexamethasone has an inhibitory effect on TSH secretion at the pituitary level. As for prolactin, our results could indicate that TRH is a more potent stimulator of prolactin secretion than of TSH secretion, or that TSH and prolactin pituitary thresholds for TRH are different.
在13名正常受试者和6名甲状腺功能减退患者中，于每日给予2毫克地塞米松三天前后，静脉注射400微克合成促甲状腺激素释放激素（TRH）后，测定血清促甲状腺激素（TSH）和催乳素水平。在正常受试者中，地塞米松抑制了基线血清水平以及TRH刺激后TSH的分泌。另一方面，它对甲状腺功能减退患者没有影响。在对照组中，地塞米松也抑制了基线血清水平，但对TRH刺激后催乳素的分泌没有影响。地塞米松对甲状腺功能减退组的催乳素水平没有影响。得出的结论是，在正常患者中，短期给予地塞米松对垂体水平的TSH分泌有抑制作用。至于催乳素，我们的结果可能表明，TRH对催乳素分泌的刺激作用比对TSH分泌的刺激作用更强，或者TSH和催乳素对TRH的垂体阈值不同。
