Davis K L, Faull K F, Hollister L E, Barchas J D, Berger P A
Psychopharmacology (Berl). 1981;72(2):155-60. doi: 10.1007/BF00431649.
The effect of IV physostigmine administration on the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) in normal subjects was determined. After an adjustment for differing CSF concentrations of probenecid, physostigmine was found to elevate CSF HVA and DOPAC concentrations. The authors discuss these changes in CSF HVA and DOPAC and their possible relationship to the ability of physostigmine to decrease the symptoms of some patients with tardive dyskinesia.
测定了静脉注射毒扁豆碱对正常受试者脑脊液（CSF）中高香草酸（HVA）和二羟基苯乙酸（DOPAC）水平的影响。在对丙磺舒不同的脑脊液浓度进行校正后，发现毒扁豆碱可提高脑脊液中HVA和DOPAC的浓度。作者讨论了脑脊液中HVA和DOPAC的这些变化及其与毒扁豆碱减轻一些迟发性运动障碍患者症状能力的可能关系。
