Iyer R, Duckworth W C, Solomon S S
Arch Intern Med. 1981 Mar;141(4):517-8.
The mechanism of hypogonadism was studied in a 63-year-old man with idiopathic hemochromatosis. Basal levels of thyroid, prolactin, cortisol, and growth hormones were normal and responded normally to appropriate provocative stimuli. Basal testosterone and gonadotropin levels were low. There was inadequate gonadotropin response to luteinizing hormone-releasing hormone and clomiphene citrate stimulation. Testosterone response to human chorionic gonadotropin was normal. Hypothalamic-pituitary dysfunction resulting in impaired gonadotropin secretion appears to be the cause of hypogonadism in hemochromatosis.
对一名患有特发性血色素沉着症的63岁男性的性腺功能减退机制进行了研究。甲状腺激素、催乳素、皮质醇和生长激素的基础水平正常，对适当的激发刺激反应也正常。睾酮和促性腺激素的基础水平较低。促性腺激素对促黄体生成素释放激素和枸橼酸氯米芬刺激的反应不足。睾酮对人绒毛膜促性腺激素的反应正常。下丘脑 - 垂体功能障碍导致促性腺激素分泌受损似乎是血色素沉着症中性腺功能减退的原因。
