[叶酸循环反应的数学描述与研究]
[Mathematical description and study of the folic acid cycle reactions].
作者信息
Vorontsov I N, Greshilov M M, Belousova A K, Gerasimova G K
出版信息
Biokhimiia. 1980 Jan;45(1):83-97.
A general description of the folic acid cycle and associate reactions of thymidilate, purines, methionine and serine biosyntheses is presented as a system of differential equations. The concrete models of this reaction complex as well as methotrexate transport into the leukemia L 1210 and Ehrlich ascite tumour cells and the dynamic inhibition of the target enzyme--dihydrofolate reductase--by methotrexate have been described and investigated. The adequacy of mathematical models to the experimental data has been demonstrated.
叶酸循环以及胸苷酸、嘌呤、蛋氨酸和丝氨酸生物合成相关反应的一般描述，以微分方程系统的形式呈现。已经描述并研究了该反应复合体的具体模型，以及甲氨蝶呤向白血病L 1210细胞和艾氏腹水瘤细胞的转运，以及甲氨蝶呤对靶酶——二氢叶酸还原酶的动态抑制作用。已经证明了数学模型与实验数据的契合度。
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