Plouin P F, Duclos J M, Menard J, Comoy E, Bohuon C, Alexandre J M
Br Med J (Clin Res Ed). 1981 Mar 14;282(6267):853-4. doi: 10.1136/bmj.282.6267.853.
Fifteen patients with hypertension due to phaeochromocytoma and 35 controls with essential hypertension were studied to assess the diagnostic value of urinary and plasma biochemical determinations in phaeochromocytoma. In every case of phaeochromocytoma the urinary concentration of vanillylmandelate, metanephrines, or adrenaline plus noradrenaline was diagnostic of the disease irrespective of whether the patient was normotensive or hypertensive at the time. Plasma determinations of adrenaline and noradrenaline, however, gave falsely negative results on three occasions. These findings suggest that urinary biochemical determinations--particularly of metanephrines--are more reliable than plasma catecholamine measurements as a test for phaeochromocytoma. The test is particularly useful in patients with intermittent hypertension.
对15例嗜铬细胞瘤所致高血压患者和35例原发性高血压对照者进行研究，以评估尿液和血浆生化测定在嗜铬细胞瘤诊断中的价值。在每例嗜铬细胞瘤患者中，无论患者当时血压正常还是高血压，尿香草扁桃酸、间甲肾上腺素或肾上腺素加去甲肾上腺素的浓度均可诊断该病。然而，血浆肾上腺素和去甲肾上腺素测定有3次出现假阴性结果。这些发现表明，作为嗜铬细胞瘤的一项检测，尿液生化测定——尤其是间甲肾上腺素的测定——比血浆儿茶酚胺测量更可靠。该检测对间歇性高血压患者特别有用。
