Tam C S, Wilson D R, Hitchman A J, Harrison J E
Calcif Tissue Int. 1981;33(2):167-72. doi: 10.1007/BF02409430.
Using the technique of short interval sequential tetracycline labeling, it was documented that the apposition of mineralized bone matrix in adult male Sprague-Dawley rats was inhibited by hydrocortisone. The inhibition occurred as early as six days after the onset of the treatment and was dose dependent over a dose range of 0.62 to 20 mg per kg body weight per day. Vitamin D2 supplements by injection protected bone from this hydrocortisone action. 64 I. U. of vitamin D2 injected daily was able to prevent the inhibition of bone apposition by 20 mg per kg body weight per day of hydrocortisone. The results imply that vitamin D or its metabolites may compete with hydrocortisone in some cellular mechanisms and support the usefulness of vitamin D supplements in the treatment and the prevention of steroid-induced osteoporosis.
运用短间隔连续四环素标记技术，已证明氢化可的松可抑制成年雄性斯普拉格 - 道利大鼠矿化骨基质的沉积。这种抑制作用在治疗开始后六天就已出现，且在每天每千克体重0.62至20毫克的剂量范围内呈剂量依赖性。通过注射补充维生素D2可保护骨骼免受氢化可的松的这种作用。每天注射64国际单位的维生素D2能够防止每天每千克体重20毫克的氢化可的松对骨沉积的抑制。这些结果表明，维生素D或其代谢产物可能在某些细胞机制中与氢化可的松竞争，并支持补充维生素D在治疗和预防类固醇诱导的骨质疏松症方面的有效性。
