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[苯丙胺刺激后氚标记氨基酸掺入大脑皮质超微结构的研究]

[Incorporation of tritiated amino acids into the ultrastructure of the cerebral cortex following phenamine stimulation].

作者信息

Nadtochiĭ V V

出版信息

Arkh Anat Gistol Embriol. 1976;71(11):78-85.

PMID:67834
Abstract

The method of electronoscopic autoradiography has revealed an increased biosynthesis of protein by neuronal and glial cells of the motor cortex of rats under phenamine stimulation. The increased level of incorporation of labelled precursors in the molecular layer of the cortex is likely to be associated with increased accumulation of newly synthetized protein in axo-dendritic synapses due to stimulation of the rapid component of the axonal transport of macromolecules. At the same time, participation of the autonomic protein-synthetizing system in the biosynthesis of synaptic proteins is not excluded. The labelled products were found to localize in the field of the thorn apparatus in processes of the "structural-functional" adaptation of synaptic entrances (A. A. Manina, 1972).

摘要

电子显微镜放射自显影法显示,在苯丙胺刺激下,大鼠运动皮层的神经元和神经胶质细胞的蛋白质生物合成增加。皮质分子层中标记前体掺入水平的增加,可能与由于大分子轴突运输快速成分的刺激,新合成蛋白质在轴突-树突突触中积累增加有关。同时,不排除自主蛋白质合成系统参与突触蛋白质的生物合成。在突触入口“结构-功能”适应过程中,标记产物定位于棘器区域(A. A. 马尼纳,1972年)。

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