Becker B, Montgomery S W, Kass M A, Shin D H
Arch Ophthalmol. 1977 May;95(5):789-90. doi: 10.1001/archopht.1977.04450050067003.
Sixteen patients with primary open-angle gaucoma (POAG) were matched as to age, sex, and race with an equal number of patients with secondary glaucoma. Although initial intraocular pressures were comparable, treatment with topical epinephrine hydrochloride, decreased intraocular pressure more than 5 mm Hg in 14 (88%) of the 16 patients with POAG but in only five (31%) of the 16 patients with secondary glaucoma (p less than .005). Eleven (69%) of the 16 patients with POAG demonstrated premature ventricular contractions during tonography as opposed to three (19%) of the 16 patients with secondary glaucoma (p less than .025). These findings suggested greater ocular as well as cardiac responsiveness to epinephrine in patients with POAG.
16例原发性开角型青光眼（POAG）患者在年龄、性别和种族方面与同等数量的继发性青光眼患者相匹配。尽管初始眼压相当，但局部应用盐酸肾上腺素治疗后，16例POAG患者中有14例（88%）眼压降低超过5 mmHg，而16例继发性青光眼患者中只有5例（31%）眼压降低超过5 mmHg（p<0.005）。16例POAG患者中有11例（69%）在眼压描记期间出现室性早搏，而16例继发性青光眼患者中只有3例（19%）出现室性早搏（p<0.025）。这些发现表明POAG患者对肾上腺素的眼部及心脏反应性更强。
