Bjaeldager P A, Christiansen E, Jensen H A, Paulev P E
Nephron. 1981;27(3):142-5. doi: 10.1159/000182040.
A high frequency of metabolic acidosis in a group of 30 patients on regular dialysis treatment initiated a study of the effect (and possible side effects) of a higher concentration of acetate in the dialysate. The concentration of acetate in the dialysate was increased from 32.6 ('low ac') to 38.2 mmol/l ('high ac'). The 'low ac' dialysis treatment changes the metabolic acidoses (mean pH = 7.34; base excess, BEb = - 8.3 mmol/l) to chronic hypocapnia (pH = 7.40; BEb = - 5.4 mmol/l). 'High ac' normalized the acid base status (pH = 7.44; BEb = -0.6 mmol/l). No side effects occurred. Since PaCO2 does not change much during hemodialysis it is convenient to look at the linearly related changes of the pH and the logarithmic standard bicarbonate concentration along iso-PCO2 lines in a log standard bicarbonate-pH-nomogram.
一组30名接受常规透析治疗的患者中代谢性酸中毒的高发生率引发了一项关于透析液中较高浓度醋酸盐的作用（以及可能的副作用）的研究。透析液中醋酸盐的浓度从32.6（“低醋酸盐”）增加到38.2 mmol/L（“高醋酸盐”）。“低醋酸盐”透析治疗将代谢性酸中毒（平均pH = 7.34；碱剩余，BEb = -8.3 mmol/L）转变为慢性低碳酸血症（pH = 7.40；BEb = -5.4 mmol/L）。“高醋酸盐”使酸碱状态正常化（pH = 7.44；BEb = -0.6 mmol/L）。未出现副作用。由于在血液透析过程中PaCO2变化不大，因此在对数标准碳酸氢盐-pH列线图中沿等PCO2线观察pH和对数标准碳酸氢盐浓度的线性相关变化很方便。
