Gragnoli G, Tanganelli I, Signorini A M, Baldini P
Minerva Med. 1981 Apr 7;72(14):869-74.
17 women affected by essential obesity were examined, 9 of whom had become obese as adults (group A) and 8 had been obese since childhood (group B). In group A, fasting and after TRH, the PRL presented higher plasmatic levels than those found in the controls. In group B the hormone showed basal values and global secretory areas higher than those observed in the controls and in group A, while incremental areas did not result different from those found in the other groups examined. In no case did IRI, GH and glycaemia undergo changes in relation to TRH. In conclusion we think that the behaviour of prolactin can be an important physiopathological characteristic, expression of the different neuroendocrine hypothalamic homeostasis existent in the heterogeneous obese population.
对17名患有原发性肥胖症的女性进行了检查，其中9名成年后肥胖（A组），8名自幼肥胖（B组）。在A组中，空腹及注射促甲状腺激素释放激素（TRH）后，催乳素（PRL）的血浆水平高于对照组。在B组中，该激素的基础值和整体分泌面积高于对照组及A组，而增量面积与其他检查组无差异。在任何情况下，胰岛素抵抗指数（IRI）、生长激素（GH）和血糖均未因TRH而发生变化。总之，我们认为催乳素的表现可能是一个重要的生理病理特征，体现了异质性肥胖人群中存在的不同神经内分泌下丘脑稳态。
