Raleigh M J, Yuwiler A, Brammer G L, McGuire M T, Geller E, Flannery J W
Psychopharmacology (Berl). 1981;72(3):241-6. doi: 10.1007/BF00431823.
The associations among twelve behaviors and three potential peripheral markers of central serotonergic activity were investigated in vervet monkeys (Cercopithecus aethiops sabaeus). The behaviors monitored included approach, heterogroom, rest, eat, avoid, be solitary, be vigilant, huddle, initiate aggress, receive aggress, and engage in sexual behavior. The biochemical parameters measured were whole blood serotonin, plasma free tryptophan, and plasma total tryptophan. Throughout the study period, intraindividual variability in both the behavioral and the biochemical measures was small, although there was substantial interindividual variability in both sets of measures. Free and total tryptophan correlated positively with approach, heterogroom, and eat, and inversely with avoid and be solitary. Whole blood serotonin correlated inversely with avoid and be solitary. These data are compatible with previously reported observations on the behavioral consequences of manipulating serotonergic systems in vervet monkeys and suggest that in normal, drug naive monkeys, free and total tryptophan are better correlates of the central serotonergic activity influencing behavior than is whole blood serotonin.
在黑长尾猴（Cercopithecus aethiops sabaeus）中研究了12种行为与中枢5-羟色胺能活性的三种潜在外周标志物之间的关联。所监测的行为包括接近、异种梳理、休息、进食、回避、独处、警惕、聚集、发起攻击、遭受攻击以及进行性行为。所测量的生化参数为全血5-羟色胺、血浆游离色氨酸和血浆总色氨酸。在整个研究期间，行为和生化测量的个体内变异性较小，尽管两组测量中个体间变异性很大。游离色氨酸和总色氨酸与接近、异种梳理和进食呈正相关，与回避和独处呈负相关。全血5-羟色胺与回避和独处呈负相关。这些数据与先前报道的关于操纵黑长尾猴5-羟色胺能系统的行为后果的观察结果一致，并表明在正常、未使用药物的猴子中，游离色氨酸和总色氨酸比全血5-羟色胺更能反映影响行为的中枢5-羟色胺能活性。
