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人类51铬红细胞在豚鼠体内的存活情况。

Survival of human 51Cr erythrocytes in guinea-pigs.

作者信息

Azikiwe A N, Castro O, Obaldiston G W, Finch S C

出版信息

Br J Exp Pathol. 1978 Jun;59(3):248-53.

PMID:678442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041355/
Abstract

A guinea-pig model for study of the survival of human erythrocytes has been developed. The T1/2 survival of human erythrocytes in guinea pigs treated with ethyl palmitate and cobra venom factor is about 3 days. This model is particularly suited to the study of the pathogenesis and therapy of certain intrinsic red cell disorders, such as sickle-cell disease.

摘要

已建立了一种用于研究人红细胞存活的豚鼠模型。在用棕榈酸乙酯和眼镜蛇毒因子处理的豚鼠中，人红细胞的T1/2存活时间约为3天。该模型特别适合于研究某些内在性红细胞疾病的发病机制和治疗方法，如镰状细胞病。

相似文献

1
Survival of human 51Cr erythrocytes in guinea-pigs.人类51铬红细胞在豚鼠体内的存活情况。
Br J Exp Pathol. 1978 Jun;59(3):248-53.
2
Oxygen-dependent circulation of sickle erythrocytes.镰状红细胞的氧依赖循环
J Lab Clin Med. 1976 Nov;88(5):732-44.
3
Trypsin-activated complex of human factor B with cobra venom factor (CVF), cleaving C3 and C5 and generating a lytic factor for unsensitized guinea pig erythrocytes. I. Generation of the activated complex.人补体B因子与眼镜蛇毒因子（CVF）的胰蛋白酶激活复合物，可裂解C3和C5，并产生针对未致敏豚鼠红细胞的溶血因子。I. 激活复合物的产生。
Biken J. 1975 Dec;18(4):193-204.
4
Experimental allergic encephalomyelitis in cobra venom factor-treated and C4-deficient guinea pigs.眼镜蛇毒因子处理的和C4缺陷型豚鼠的实验性变应性脑脊髓炎
Ann Neurol. 1978 Nov;4(5):427-30. doi: 10.1002/ana.410040507.
5
Survival of human sickle-cell erythrocytes in heterologous species: response to variations in oxygen tension.人类镰状细胞红细胞在异种物种中的存活：对氧张力变化的反应。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2356-9. doi: 10.1073/pnas.70.8.2356.
6
Action of Naja naja venom on erythrocytes of laboratory animals.眼镜蛇毒液对实验动物红细胞的作用。
Indian J Med Res. 1982 Dec;76:882-7.
7
Trypsin-activated complex of human factor B with cobra venom factor (CVF), cleaving C3 and C5 and generating a lytic factor for unsensitized guinea pig erythrocytes. II. Physico-chemical characterization of the activated complex.人补体B因子与眼镜蛇毒因子（CVF）的胰蛋白酶激活复合物，可裂解C3和C5并产生针对未致敏豚鼠红细胞的溶细胞因子。II. 激活复合物的理化特性
Biken J. 1975 Dec;18(4):205-14.
8
Natural killer cell- and macrophage mediated discordant guinea pig-->rat xenograft rejection in the absence of complement, xenoantibody and T cell immunity.在缺乏补体、异种抗体和T细胞免疫的情况下，自然杀伤细胞和巨噬细胞介导豚鼠对大鼠异种移植的不一致排斥反应。
Transplantation. 2000 Jul 15;70(1):86-93.
9
Role of antibody and complement in the immune clearance and destruction of erythrocytes. II. Molecular nature of IgG and IgM complement-fixing sites and effects of their interaction with serum.抗体和补体在红细胞免疫清除与破坏中的作用。II. IgG和IgM补体结合位点的分子性质及其与血清相互作用的影响
J Clin Invest. 1972 Mar;51(3):583-9. doi: 10.1172/JCI106847.
10
Selective lysis of virus-infected cells by cobra snake cytotoxins: A sendai virus, human erythrocytes, and cytotoxin model.眼镜蛇蛇细胞毒素对病毒感染细胞的选择性裂解：仙台病毒、人类红细胞和细胞毒素模型。
Biochem Biophys Res Commun. 1999 Oct 14;264(1):63-8. doi: 10.1006/bbrc.1999.1483.

本文引用的文献

1
The effects of a cobra venom factor and ethyl palmitate on the prolongation of survival of heterologous erythrocytes.眼镜蛇毒因子和棕榈酸乙酯对延长异种红细胞存活时间的影响。
Yale J Biol Med. 1970 Dec;43(3):173-6.
2
The effect of hemoglobin carbamylation on the survival of human sickle cell erythrocytes in rats.血红蛋白氨甲酰化对人镰状细胞红细胞在大鼠体内存活的影响。
Yale J Biol Med. 1974 Mar;47(1):55-60.
3
The development of a heterologous transfusion technique: application to sickle cell disease.一种异源输血技术的研发：应用于镰状细胞病
Conn Med. 1974 Jul;38(7):338-41.
4
Survival of human sickle-cell erythrocytes in heterologous species: response to variations in oxygen tension.人类镰状细胞红细胞在异种物种中的存活：对氧张力变化的反应。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2356-9. doi: 10.1073/pnas.70.8.2356.
5
Mechanism of ethyl palmitate and cobra venom factor enhancement of heterologous erythrocyte survival.棕榈酸乙酯和眼镜蛇毒因子增强异种红细胞存活的机制。
Proc Soc Exp Biol Med. 1974 Oct;147(1):106-9. doi: 10.3181/00379727-147-38290.
6
Sickle cell resistance to in vivo hypoxia.镰状细胞对体内缺氧的抗性。
Nature. 1974 Oct 18;251(5476):620-1. doi: 10.1038/251620a0.
7
Correction of the permeability defect in hereditary stomatocytosis by dimethyl adipimidate.用己二酸二甲酯纠正遗传性口形红细胞增多症的通透性缺陷
N Engl J Med. 1976 May 27;294(22):1200-4. doi: 10.1056/NEJM197605272942202.
8
Oxygen-dependent circulation of sickle erythrocytes.镰状红细胞的氧依赖循环
J Lab Clin Med. 1976 Nov;88(5):732-44.