Passath A, Leb G, Goebel R
Acta Med Austriaca. 1980;7(3):80-7.
TRH (40 mg) was given orally to 122 patients with divers thyroid status. In euthyroidism, TRH induced TSH response ranged from 2.5 microU to 45 microU TSH, measured three hours after oral administration. TSH values were threefold higher following oral TRH (mean 24.5 microU) as compared to intravenous TRH-test using 200 microgram TRH (mean 7.05 microU). No exaggerated TSH response were found in patients on oral contraceptives and in euthyroid nodular goiter. Preclinical hypothyroidism was present in 50% in patients with previous partial thyroidectomy and only 15% of patients with blunted TSH response on an thyroid hormone regimen of 70 microgram thyroxine daily. Oral TRH test was negative in every patient with normal serum hormone levels under antithyroid drug therapy.
对122例甲状腺状态各异的患者口服促甲状腺激素释放激素（TRH，40毫克）。在甲状腺功能正常的情况下，口服给药三小时后测得，TRH诱导的促甲状腺激素（TSH）反应范围为2.5微单位至45微单位。与使用200微克TRH的静脉TRH试验（平均7.05微单位）相比，口服TRH后的TSH值高出三倍（平均24.5微单位）。口服避孕药的患者和甲状腺功能正常的结节性甲状腺肿患者未发现TSH反应过度。既往接受部分甲状腺切除术的患者中，50%存在临床前甲状腺功能减退，而在每日服用70微克甲状腺素的甲状腺激素治疗方案下，TSH反应迟钝的患者中只有15%。在接受抗甲状腺药物治疗且血清激素水平正常的每位患者中，口服TRH试验均为阴性。
