Dykes P J, Marks R, Smith P
Br J Dermatol. 1978 Jun;98(6):611-8. doi: 10.1111/j.1365-2133.1978.tb03578.x.
The in vitro incorporation of 14C acetate by the epidermis has been studied in patients with autosomal dominant ichthyosis and in patients with a dry, itchy, slightly scaly skin associated with a disorder of the small bowel. Analysis of 14C acetate containing lipid moieties by thin layer chromatography has indicated that there are both quantitative and qualitative differences in the uptake of 14C acetate between autosomal dominant ichthyosis and normal. In particular an increased incorporation into the triglyceride and phosphatidyl choline fractions was noted. No such differences were apparent in those patients with disorders of the small bowel. In addition the in vitro incorporation of radioactively labelled thymidine, proline and histidine has been studied in these patients. In both groups of patients the rate of incorporation of tritiated thymidine and histidine into epidermal macromolecules was found not to differ significantly from normal. On the other hand the rate of incorporation of tritiated proline was increased in both groups of patients.
对常染色体显性鱼鳞病患者以及患有与小肠疾病相关的干燥、瘙痒、轻度鳞屑性皮肤的患者，研究了表皮对¹⁴C醋酸盐的体外掺入情况。通过薄层色谱法对含¹⁴C醋酸盐的脂质部分进行分析表明，常染色体显性鱼鳞病患者与正常人之间在¹⁴C醋酸盐摄取方面存在量和质的差异。特别值得注意的是，甘油三酯和磷脂酰胆碱部分的掺入增加。在患有小肠疾病的患者中未观察到此类差异。此外，还研究了这些患者对放射性标记的胸腺嘧啶核苷、脯氨酸和组氨酸的体外掺入情况。在两组患者中，发现氚标记的胸腺嘧啶核苷和组氨酸掺入表皮大分子的速率与正常情况无显著差异。另一方面，两组患者中氚标记脯氨酸的掺入速率均有所增加。
