Osswald P M, Hartung H J, Klose R, Spier R
Anaesthesist. 1981 Feb;30(2):71-6.
The effect of prolonged inspiration time and PEEP on compliance, haemodynamics and gas exchange was studied on 15 patients, who were ventilated because of respiratory distress syndrome. The patients were ventilated by the Servoventilator 900 BR connected with a calculation unit. The inspiration time varied from 35 to 70%, the PEEP from 0 to 20 cm H2O. All patients were ventilated with constant tidal volumes (10-15 ml/kg b.w.). The compliance rose from 48 ml/H2O (ZEEP) to 61,5 ml/cm H2O (PEEP + 8 ml H2O). A further increase of PEEP caused a decrease of compliance to 48 ml/cm H2O (PEEP + 20 cm H2O). A prolongation of inspiration time of up to 53% showed an augmentation of compliance from 48 ml/cm H2O to 53 ml/cm H2O. Both modes of assisted ventilation caused an improvement of alveolar ventilation. The simultaneous consideration of various parameters of gas exchange, compliance and haemodynamics guaranteed the optimal mode of ventilation and minimal side effects.
对15例因呼吸窘迫综合征而接受通气治疗的患者，研究了延长吸气时间和呼气末正压（PEEP）对顺应性、血流动力学和气体交换的影响。患者通过与计算单元相连的Servoventilator 900 BR呼吸机进行通气。吸气时间从35%变化到70%，PEEP从0变化到20 cm H₂O。所有患者均以恒定潮气量（10 - 15 ml/kg体重）进行通气。顺应性从48 ml/H₂O（零PEEP）升至61.5 ml/cm H₂O（PEEP + 8 cm H₂O）。PEEP进一步增加导致顺应性降至48 ml/cm H₂O（PEEP + 20 cm H₂O）。吸气时间延长至53%时，顺应性从48 ml/cm H₂O增至53 ml/cm H₂O。两种辅助通气模式均使肺泡通气得到改善。同时考虑气体交换、顺应性和血流动力学的各种参数，确保了最佳通气模式和最小副作用。
