硝酸甘油在妊娠绵羊体内的血浆水平及心血管效应

Plasma levels and cardiovascular effect of nitroglycerin in pregnant sheep.

作者信息

de Rosayro M, Nahrwold M L, Hill A B, Tait A R, Busch M D, Kirsh M M

出版信息

Can Anaesth Soc J. 1980 Nov;27(6):560-4. doi: 10.1007/BF03006886.

Abstract

The cardiovascular effects and blood levels of intravenous nitroglycerin in mother and foetus were studied in normotensive and hypertensive ewes. Although nitroglycerin produced a reduction in uterine blood flow following a decrease in blood pressure, there was little if any incidence of adverse effects in the foetus. Nitroglycerin was detected in all but two samples of foetal arterial blood but the foetal/maternal artery ratio was only 0.04. Nitroglycerin merits further evaluation for the treatment of acute hypertensive episodes in the preeclamptic patient.

摘要

在血压正常和高血压的母羊中研究了静脉注射硝酸甘油对母体和胎儿的心血管影响及血药浓度。尽管硝酸甘油在血压下降后会使子宫血流量减少，但胎儿几乎没有出现不良反应。除两份胎儿动脉血样本外，其他所有样本均检测到硝酸甘油，但胎儿与母体动脉血药浓度比值仅为0.04。硝酸甘油在治疗先兆子痫患者的急性高血压发作方面值得进一步评估。