Smith J B, Manning F A, Palahniuk R J
Can Anaesth Soc J. 1975 Jul;22(4):449-59. doi: 10.1007/BF03004859.
Maternal and foetal cardiovascular, blood gas and acid-base changes were studied during 90 minutes of methoxyflurane anaesthesia. At 1.0 and 1.5 MAC anaesthesia, despite slight to moderate falls in maternal blood pressure, cardiac output and uterine blood flow, no serious foetal deterioration was seen. 2.0 MAC methoxyflurane was associated with marked falls in maternal blood pressure, cardiac output and uterine blood flow. Foetal hypoxaemia and a mixed respiratory and metabolic acidosis developed. Little foetal cardiovascular depression was seen with any level of anaesthesia. There was no direct effect of methoxyflurane on the uterine vasculature.
在甲氧氟烷麻醉的90分钟内，对母体和胎儿的心血管、血气及酸碱变化进行了研究。在1.0和1.5倍最低肺泡有效浓度（MAC）麻醉时，尽管母体血压、心输出量和子宫血流量有轻度至中度下降，但未见胎儿严重恶化。2.0倍MAC的甲氧氟烷与母体血压、心输出量和子宫血流量的显著下降有关。胎儿出现低氧血症以及混合性呼吸和代谢性酸中毒。在任何麻醉水平下，胎儿心血管抑制均较轻。甲氧氟烷对子宫血管系统无直接影响。
