Guthrie R D, Standaert T A, Hodson W A, Woodrum D E
J Appl Physiol Respir Environ Exerc Physiol. 1981 May;50(5):956-61. doi: 10.1152/jappl.1981.50.5.956.
To determine the independent effects of sleep state, gestational age, and postnatal age on eucapnic ventilation and steady-state CO2 sensitivity, nine premature (146 +/- 3 days) and eight full-term (168 +/- 2 days) monkeys, Macaca nemestrina, from accurately timed conceptions were studied serially over the first 3 wk of life. Minute volume (VE)/kg,tidal volume (VT)/kg, and respiratory frequency were quantitated during rapid-eye-movement sleep (REM) and nonrapid-eye-movement sleep (NREM)in room air and when animals were breathing varied concentrations of cO2 in 21% O2. Eucapnic VE/kg and CO2 sensitivity [(deltaVE/kg)/delta PaCO2] increased progressively with advancing postnatal age during NREM sleep in grouped term and premature animals. CO2 sensitivity was not significantly different between REM and NREM sleep except in full-term animals at the highest postconceptual age studied (189 +/- 2 days) when [(delta VE/kg)/delta PaCO2] was lower in REM sleep than in NREM sleep (209 +/- 54 vs. 301 +/- 71 ml.min-1.kg-1.Torr-1; P less than 0.05, paired-t test). Gestational age had no measurable effect on eucapnic ventilation or CO2 sensitivity. These results support the hypothesis that REM sleep-induced depression of CO2 sensitivity develops in the neonatal monkey with advancing postconceptual age.
为了确定睡眠状态、胎龄和出生后年龄对正常碳酸通气和稳态二氧化碳敏感性的独立影响，对9只早产（146±3天）和8只足月（168±2天）的食蟹猴（Macaca nemestrina）进行了研究，这些猴子来自精确计时的受孕，在出生后的前3周内进行了连续观察。在快速眼动睡眠（REM）和非快速眼动睡眠（NREM）期间，以及动物在21%氧气中呼吸不同浓度二氧化碳时，测量每千克体重的分钟通气量（VE）、每千克体重的潮气量（VT）和呼吸频率。在足月和早产动物分组中，非快速眼动睡眠期间，正常碳酸VE/kg和二氧化碳敏感性[（δVE/kg）/δPaCO2]随出生后年龄的增加而逐渐增加。除了在研究的最高孕龄（189±2天）的足月动物中，快速眼动睡眠和非快速眼动睡眠之间的二氧化碳敏感性没有显著差异，此时快速眼动睡眠中的[（δVE/kg）/δPaCO2]低于非快速眼动睡眠（209±54对301±71 ml·min-1·kg-1·Torr-1；P＜0.05，配对t检验）。胎龄对正常碳酸通气或二氧化碳敏感性没有可测量的影响。这些结果支持了这样的假设，即随着孕龄的增加，新生猴会出现快速眼动睡眠诱导的二氧化碳敏感性降低。
