Reed M D, Halpin T C, Herzig R H, Gross S
JPEN J Parenter Enteral Nutr. 1981 Jan-Feb;5(1):37-9. doi: 10.1177/014860718100500137.
Two adolescents who underwent successful allogeneic bone marrow transplantation were nutritionally managed on a fat-free cyclic parenteral nutrition (PN) regimen. Serum concentrations of prealbumin, albumin, and transferrin were prospectively evaluated to assess the efficacy of nutritional therapy. Both patients tolerated the cyclic PN metabolically. Serial albumin and transferrin concentrations varied slightly and were less sensitive indices of changing nutritional status. In contrast, prealbumin concentrations decreased uniformly during periods of metabolic stress. At the cessation of Pn therapy, all serum proteins were within the normal range. Cyclic PN appears to be a safe, practical approach to the nutritional management of patients undergoing bone marrow transplantation.
两名接受同种异体骨髓移植成功的青少年患者采用无脂周期性肠外营养（PN）方案进行营养管理。前瞻性评估血清前白蛋白、白蛋白和转铁蛋白浓度，以评估营养治疗的效果。两名患者在代谢方面均耐受周期性PN。血清白蛋白和转铁蛋白浓度呈轻微变化，是营养状况改变的较不敏感指标。相比之下，前白蛋白浓度在代谢应激期间一致下降。在PN治疗停止时，所有血清蛋白均在正常范围内。周期性PN似乎是骨髓移植患者营养管理的一种安全、实用的方法。
