Metabolism of [14C] terbutryn (2-(t-butylamino)-4-(ethylamino)-6-(methylthio-s-triazine) by rats and goat.
作者信息
Larsen G L, Bakke J E, Feil V J
出版信息
Biomed Mass Spectrom. 1978 Jun;5(6):382-900. doi: 10.1002/bms.1200050604.
PMID:678607
Abstract
Sixteen metabolites of terbutryn were isolated from the urine and feces of either rats or a goat given single oral doses of terbutryn-14C. The metabolites resulted from one or more of the following changes: S-demethylation, conversion of the methylthio group to a hydroxy group; N-deethylation; oxidation of the terminal carbon of the ethyl group to a carboxylic acid; oxidation of a terminal carbon of the t-butyl group to either an alcohol or a carboxylic acid; or conjugation with glucuronic acid.
摘要
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