Metabolism of [14C] terbutryn (2-(t-butylamino)-4-(ethylamino)-6-(methylthio-s-triazine) by rats and goat.

Sixteen metabolites of terbutryn were isolated from the urine and feces of either rats or a goat given single oral doses of terbutryn-14C. The metabolites resulted from one or more of the following changes: S-demethylation, conversion of the methylthio group to a hydroxy group; N-deethylation; oxidation of the terminal carbon of the ethyl group to a carboxylic acid; oxidation of a terminal carbon of the t-butyl group to either an alcohol or a carboxylic acid; or conjugation with glucuronic acid.