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[几种芳香胺体内治疗后的DNA损伤:2,4-二氨基甲苯、4-氨基苯(苯胺)和对二甲氨基偶氮苯(奶油黄)]

[DNA damage after treatment in-vivo with several aromatic amines: 2,4-diaminotoluene, 4-aminobenzene (aniline) and paradimethylaminoazobenzene (butter yellow)].

作者信息

Russo P, Vecchio D, Balbi C, Parodi S, Santi L

出版信息

Boll Soc Ital Biol Sper. 1981 Jan 30;57(2):131-7.

PMID:6786305
Abstract

Three aromatic amines, 2,4 diaminotoluene, aminobenzene and paradimethylaminoazobenzene were examined for their capability of damaging rat liver DNA. Compounds were tested by the "in vivo"/DNA alcaline elution assay. 2,4 diaminotoluene was very positive, aminobenzene weakly positive, paradimethylaminoazobenzene probably negative. All the compounds were tested at doses already clearly toxic.

摘要

研究了三种芳香胺,即2,4-二氨基甲苯、苯胺和对二甲氨基偶氮苯对大鼠肝脏DNA的损伤能力。采用“体内”/DNA碱性洗脱试验对这些化合物进行检测。2,4-二氨基甲苯呈强阳性,苯胺呈弱阳性,对二甲氨基偶氮苯可能呈阴性。所有化合物均在已明确有毒的剂量下进行检测。

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