Myshliakova N V, Klusha V E, Chipens G I
Biokhimiia. 1980 Oct;45(10):1761-6.
The comparative effects of thyroliberin (TRH), pentagastrin, C-terminal tripeptides of gastrin (MNF), luliberin (RPG) and its analog (RPF), oxytocin (PLG) and N-terminal tripeptide of angiotensin (NRV) on the glucose concentration in mouse blood, as well as the interrelationship between the peptides under study and insulin and somatostatin, were studied. It was found that all the peptides (except PLG) at doses 5, 50 and 100 mg/kg (intraperitoneally) exert a hypoglycemic effect comparable to that of insulin at the dose of 0,15 MU/kg (subcutaneously). The dose-dependent effect is observed only in the case of TRH. Somatostatin reverses the hypoglycemic action of TRH, MNF and NRV. TRH and RPF decrease the glucose-induced rise in insulin concentration measured by RIA. The structure-activity relationship and possibility of the formation of endogenous peptide hormone fragments as products of hormone molecules enzymatic cleavage and their glucoregulatory role are discussed.
研究了促甲状腺素释放激素（TRH）、五肽胃泌素、胃泌素C末端三肽（MNF）、促黄体生成素释放激素（RPG）及其类似物（RPF）、催产素（PLG）和血管紧张素N末端三肽（NRV）对小鼠血糖浓度的比较作用，以及所研究的这些肽与胰岛素和生长抑素之间的相互关系。结果发现，所有肽（PLG除外）在5、50和100mg/kg（腹腔注射）剂量时产生的降血糖作用与0.15MU/kg（皮下注射）剂量的胰岛素相当。仅TRH呈现剂量依赖性效应。生长抑素可逆转TRH、MNF和NRV的降血糖作用。TRH和RPF可降低放射免疫分析法测定的葡萄糖诱导的胰岛素浓度升高。文中讨论了结构-活性关系以及作为激素分子酶解产物的内源性肽激素片段形成的可能性及其糖调节作用。
