Fedorov N A, Gorbunova N A, Balakina T A, Kolpikov V N
Biull Eksp Biol Med. 1978;86(7):116-20.
Vascular-thrombocytic and plasma hemostasis was studied in dogs after blood loss (40--50 ml/kg weight) and subsequent hypervolemic (60--65 ml/kg weight) transfusion of homologous (from 3 donors) platelet and leukocyte rich in plasma. After a short phase of hypercoagulation all the tested dogs displayed hypocoagulation accompanied by a decrease in the count of platelets and a fall of their aggregation function, prolongation of bleeding time, diminution of capillary wall resistance, a decrease of plasma fibrinogen concentration and factor XIII activity, and by a rise of blood fibrinolytic activity. The data obtained show the development of the acute disseminated intravascular coagulation syndrome (DIC). DIC model is porposed on the basis of the results obtained.
对失血（40 - 50毫升/千克体重）后再进行高血容量（60 - 65毫升/千克体重）同源（来自3个供体）富含血小板和白细胞血浆输注的犬类进行血管 - 血小板及血浆止血研究。在短暂的高凝阶段后，所有受试犬均出现低凝状态，伴有血小板计数减少、其聚集功能下降、出血时间延长、毛细血管壁阻力降低、血浆纤维蛋白原浓度和因子ⅩⅢ活性降低，以及血液纤溶活性升高。所获数据显示急性弥散性血管内凝血综合征（DIC）的发生。基于所获结果提出了DIC模型。
