Jarisch R, Roth A, Boltz A, Sandor I
Clin Allergy. 1981 Mar;11(2):155-60. doi: 10.1111/j.1365-2222.1981.tb01579.x.
Fifty patients with suspected allergy to penicillin were tested. Skin tests were done with Na-penicillin G and penicilloyl-polylysin. Specific IgE antibody assays were done with penicilloyl G and V conjugates by means of RAST. The overall agreement between skin test and RAST results was 87%, borderline cases not included. In one case, skin tests were positive to penicillamine only, while RAST for penicilloyl G and V both proved to be positive. One case of penicillin allergy could be diagnosed in vitro post mortem only. Two cases of Hoigné syndrome showed no evidence of allergy. Patterns of skin manifestations varied but urticaria was the most commonly seen feature. Twenty patients without adverse reactions to penicillin treatment and seven patients who had not received penicillin over the last 10 years served as controls. None of them were positive in either skin tests of RAST. Two or our twenty control patients developed penicillin allergy during the study. Both showed positive RAST results.
对50名疑似对青霉素过敏的患者进行了检测。用青霉素G钠和青霉噻唑聚赖氨酸进行皮肤试验。通过放射性变应原吸附试验（RAST）用青霉噻唑G和V偶联物进行特异性IgE抗体检测。皮肤试验和RAST结果之间的总体一致性为87%，不包括临界病例。有1例仅对青霉胺皮肤试验呈阳性，而对青霉噻唑G和V的RAST均呈阳性。仅1例青霉素过敏病例可在死后进行体外诊断。2例霍伊内综合征未显示过敏迹象。皮肤表现形式多样，但荨麻疹是最常见的特征。20名对青霉素治疗无不良反应的患者和7名在过去10年中未接受过青霉素治疗的患者作为对照。他们在皮肤试验或RAST中均无阳性结果。我们的20名对照患者中有2名在研究期间出现了青霉素过敏。两者的RAST结果均呈阳性。
