免疫球蛋白E抗体与抗感染能力。I. 选择性抑制大鼠的免疫球蛋白E抗体反应会降低其对旋毛虫感染的抵抗力及嗜酸性粒细胞反应。
IgE antibody and resistance to infection. I. Selective suppression of the IgE antibody response in rats diminishes the resistance and the eosinophil response to Trichinella spiralis infection.
作者信息
Dessein A J, Parker W L, James S L, David J R
出版信息
J Exp Med. 1981 Feb 1;153(2):423-36. doi: 10.1084/jem.153.2.423.
Abstract
Selective suppression of the total IgE antibody response has been achieved in rats by injection of rabbit anti-rat epsilon-chain antibodies. This IgE-specific suppression was maintained during the course of a natural infection by the nematode Trichinella spiralis. Depletion of the IgE antibody response resulted in a marked reduction of the number of eosinophils attracted to the T. spiralis larvae encysted in striated muscle. Blood eosinophilia following T. spiralis infection, although reaching normal peak levels, was abbreviated in IgE-suppressed animals. Moreover, IgE-depleted animals were more susceptible to the infection; they harbored two to three times more larvae encysted in their muscles than their control litter mates.
摘要
通过注射兔抗大鼠ε链抗体，已在大鼠中实现了对总IgE抗体反应的选择性抑制。在旋毛虫线虫自然感染过程中，这种IgE特异性抑制得以维持。IgE抗体反应的耗竭导致吸引到横纹肌中包囊化的旋毛虫幼虫处的嗜酸性粒细胞数量显著减少。旋毛虫感染后的血液嗜酸性粒细胞增多，尽管达到正常峰值水平，但在IgE抑制的动物中有所缩短。此外，IgE耗竭的动物对感染更易感；它们肌肉中包囊化的幼虫数量比其对照同窝仔多两到三倍。
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