Zalejski S, Pakszys W
Neurol Neurochir Pol. 1980;14(6):617-20.
Clinical and electroencephalographic investigations were performed and the diphenylhydantoin level was determined in the serum in a homogenous group of 32 young males aged 20-22 years staying in hospital. The spectrophotometric determination of the drug was found to be useful. The effect of therapeutic DPH level on regression of abnormal EEG tracings was demonstrated to be statistically significant. Absence of improvement or exacerbation of EEG changes should arouse the suspicion that the levels of 10 to 20 micrograms/ml of DPH in the serum has not been attained or has been exceeded.
对32名年龄在20至22岁住院的年轻男性进行了临床和脑电图检查，并测定了血清中苯妥英水平。发现用分光光度法测定该药物很有用。治疗性苯妥英水平对异常脑电图描记图消退的影响经统计学证明具有显著意义。脑电图变化若没有改善或加重，应怀疑血清中苯妥英水平未达到或已超过10至20微克/毫升。
