Tate-Ostroff B, Stetson M H
Neuroendocrinology. 1981 Jun;32(6):325-9. doi: 10.1159/000123181.
This investigation was designed to determine if a correlation exists between a change in the response of the hypothalamo-hypophysial axis to castration and the onset of refractoriness in male hamsters exposed to short days (in this case LD 6:18). The castration response, here defined as a significant increase in serum gonadotropins over levels in intact males, in males exposed to short days for 2 weeks was no different from that observed in long day males. On weeks 4 and 6 the response was greatly attenuated, and on weeks 8 and 10 no castration response was observed. Refractoriness was first observed in a few animals exposed to LD 6:18 for 8 weeks, and in increasing numbers of animals on weeks 10, 12, 13 and 14 of short-day treatment. Thus, short day exposure results in a simultaneous loss of response of the hypothalamo-hypophysial axis to castration and initiation of refractoriness.
本研究旨在确定下丘脑 - 垂体轴对去势的反应变化与暴露于短日照（在本研究中为LD 6:18）的雄性仓鼠不应期的开始之间是否存在相关性。去势反应在此定义为血清促性腺激素水平比完整雄性显著升高，暴露于短日照2周的雄性仓鼠的去势反应与长日照雄性仓鼠中观察到的无差异。在第4周和第6周，反应大大减弱，在第8周和第10周未观察到去势反应。在暴露于LD 6:18 8周的少数动物中首次观察到不应期，在短日照处理的第10、12、13和14周，出现不应期的动物数量不断增加。因此，短日照暴露导致下丘脑 - 垂体轴对去势的反应同时丧失和不应期的开始。
