Campbell A, Baldessarini R J
Psychopharmacology (Berl). 1981;73(3):219-22. doi: 10.1007/BF00422406.
Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1.5 years had strikingly increased sensitivity to the activity-inhibiting and cataleptic effects of the drug. The efficacy of haloperidol on all tests in 110-day old rats was indistinguishable whether food was available continuously, or restricted to reduce body weight by 55%, indicating that the effects of maturation are due to aging and not to increasing body weight. The effects may be due to altered drug metabolism or altered sensitivity of the central nervous system to neuroleptic agents. Clinical impressions too, indicate that immature and elderly patients are more sensitive to these and other psychotropic drugs than are young adults.
对18至825日龄的雄性斯普拉格-道利大鼠评估了对不同剂量氟哌啶醇（腹腔注射，剂量为0和0.05 - 10毫克/千克）的反应。在成熟的前1.5年中，僵住症、眼睑下垂和全身运动活动抑制表现出对该药物的敏感性随年龄稳步下降，而1.5岁以上的大鼠对该药物的活动抑制和僵住症作用的敏感性显著增加。在110日龄大鼠中，无论食物是持续供应还是限制供应以减轻体重55%，氟哌啶醇在所有测试中的效果都没有差异，这表明成熟的影响是由于衰老而非体重增加。这些影响可能是由于药物代谢改变或中枢神经系统对抗精神病药物的敏感性改变所致。临床观察也表明，未成熟和老年患者比年轻成年人对这些及其他精神药物更敏感。
