Feldon J, Gray J A
Psychopharmacology (Berl). 1981;73(3):269-75. doi: 10.1007/BF00422416.
Two experiments are reported, in which rats were run in a straight alley for food reward with or without injections of the anti-anxiety drug, chlordiazepoxide (CDP). The experiments were directed to two questions. (1) Can one predict the effects of CDP from knowledge of the effects of a second anti-anxiety drug, sodium amylobarbitone (SA) (2) can the effects of CDP be predicted from the hypothesis that anti-anxiety drugs attenuate responses to conditioned frustrative stimuli? The experiments examined the effects of CDP on the partial reinforcement extinction effect (PREE) at one trial a day. CDP injected throughout acquisition and extinction reduced the PREE. This effect was probably due to the presence of the drug during acquisition. Injected during extinction only, CDP increased resistance to extinction in both continuous and partial reinforcement groups. These effects of CDP were closely similar to those previously reported for SA, thus answering question (1) in the affirmative. The effects of CDP on the PREE were also consistent with the conditioned-frustration hypothesis (question 2).
本文报告了两项实验，实验中大鼠在直道迷宫中奔跑以获取食物奖励，实验过程中大鼠被注射或未被注射抗焦虑药物氯氮卓（CDP）。这些实验针对两个问题展开。（1）能否根据另一种抗焦虑药物戊巴比妥钠（SA）的作用来预测CDP的作用？（2）能否根据抗焦虑药物会减弱对条件性挫折刺激的反应这一假设来预测CDP的作用？实验研究了CDP对每天一次试验的部分强化消退效应（PREE）的影响。在整个习得和消退过程中注射CDP会降低PREE。这种效应可能是由于在习得过程中存在该药物。仅在消退过程中注射时，CDP增加了连续强化组和部分强化组对消退的抵抗力。CDP的这些效应与先前报道的SA的效应非常相似，从而对问题（1）给出了肯定的回答。CDP对PREE的影响也与条件性挫折假设（问题2）一致。
