Kasik J E, Monick M
Antimicrob Agents Chemother. 1981 Jan;19(1):134-8. doi: 10.1128/AAC.19.1.134.
Comparison of the in vivo and in vitro immunosuppressive activities of the five rifamycins with their in vitro antibacterial and anti-ribonucleic acid polymerase activities indicated that correlation was poor. Examination of their activities on mitogen-induced blastogenesis in human peripheral blood leukocytes and inhibition of delayed-type hypersensitivity to partially purified protein derivative in immunized mice demonstrated that correlation was usually good. Antibacterial activity in cultures and the activities of the rifamycins inhibiting deoxyribonucleic acid-dependent ribonucleic acid polymerase appeared to correlate well. However, when these two types of activity, antiimmune and antibacterial, were compared, correlation was poor on occasion and indicated that the antiimmune activities and antibacterial activities of the rifamycins are probably not related.
对五种利福霉素的体内和体外免疫抑制活性与其体外抗菌活性及抗核糖核酸聚合酶活性进行比较，结果表明相关性较差。检测它们对人外周血白细胞有丝分裂原诱导的细胞增殖的活性，以及对免疫小鼠中对部分纯化蛋白衍生物迟发型超敏反应的抑制作用，结果表明相关性通常良好。培养物中的抗菌活性与利福霉素抑制依赖脱氧核糖核酸的核糖核酸聚合酶的活性似乎相关性良好。然而，当比较这两种活性，即抗免疫活性和抗菌活性时，有时相关性较差，这表明利福霉素的抗免疫活性和抗菌活性可能没有关联。
