[Effect of the dynamic factors of space flight on the mutagenic effect of radiation. II. Development of recessive lethals and loss of X-chromosomes in Drosophila melanogaster oocytes].

The modifying effect of dynamic space-flight factors on radiation damage of Drosophila oocytes was measured by the frequencies of X-chromosomal non-disjunction, loss and sex-linked recessive lethals. It has been shown that with a slight increase in the non-disjunction frequency, dynamic factors did not influence the frequency of loss events in irradiated oocytes. The yield of recessive lethal mutations increased in irradiated oocytes-7 both upon pre- and postradiation action of dynamic factors. A similar increase in the frequency of recessive lethals was observed after an additional action of acceleration on irradiated oocytes. It is assumed that the modifying effect of dynamic factors is associated with repair repression at early stages of radiation damage.