自主呼吸的麻醉兔在缺氧时的肺力学

Pulmonary mechanics during hypoxia in spontaneously breathing anesthetized rabbits.

作者信息

Delpierre S, Fornaris E, Fornaris M, Grimaud C

出版信息

J Auton Nerv Syst. 1980 Dec;2(4):391-401. doi: 10.1016/0165-1838(80)90036-3.

Abstract

Changes in lung mechanics were measured during hypoxia (FIO2 = 0.10 during 5 min) in spontaneously breathing anesthetized rabbits. In intact animals, hypoxia induced scattered variations in total lung resistance (RL) (decrease, increase or no alteration) and dynamic lung compliance (CL), whereas in carotid body denervated animals it was accompanied by an almost constant decrease in RL (-12%); but if a subsequent vagotomy was performed, there was no significant variation in RL. In animals which had been only vagotomized, CL decreased significantly during hypoxia (-23%) without any associated change in RL. So, the arterial chemoreceptor mediated bronchoconstrictor effects due to hypoxia could be normally masked by the dilator effects (metabolic and/or sympathetic) on the airways.

摘要

在自主呼吸的麻醉兔中，于低氧期间（5分钟内吸入氧分数为0.10）测量肺力学变化。在完整动物中，低氧诱导总肺阻力（RL）出现散在变化（降低、升高或无改变）以及动态肺顺应性（CL）变化，而在切除颈动脉体的动物中，低氧伴随着RL几乎持续降低（-12%）；但如果随后进行迷走神经切断术，则RL无显著变化。在仅进行迷走神经切断术的动物中，低氧期间CL显著降低（-23%），而RL无相关变化。因此，低氧引起的动脉化学感受器介导的支气管收缩效应通常可被气道上的扩张效应（代谢性和/或交感神经性）所掩盖。