前列腺素E1对促甲状腺素诱导的蛙脑垂体神经中间叶α-促黑素释放的刺激作用。
Stimulatory effect of prostaglandin E1 on thyroliberin-induced alpha-melanotropin release from perifused neuro-intermediate lobes of frog pituitary gland.
作者信息
Leroux P, Tonon M C, Jégou S, Delarue C, Leboulenger F, Netchitaïlo P, Vaudry H
出版信息
Prostaglandins. 1981 Apr;21(4):599-608. doi: 10.1016/0090-6980(81)90008-3.
A possible direct effect of prostaglandins on alpha-melanotropin (alpha-MSH) release at the level of the intermediate lobe of the frog pituitary was investigated in vitro using a perifusion system technique. The effect of prostaglandins was studied on both spontaneous and TRH-stimulated alpha-MSH secretion. No significant effect of PGE1, PGE2, PGF1 alpha or PGF2 alpha on basal release of alpha-MSH could be detected. Indomethacin did not alter the alpha-MSH release induced by TRH. Conversely a significant increase in TRH-induced alpha-MSH secretion was observed in the presence of 1 x 10(-6) M PGE1. This magnifying effect was directly related to the concentration of TRH for doses ranging from 1 x 10(-8) M to 1 x 10(-6) M.
利用灌流系统技术在体外研究了前列腺素对蛙脑垂体中间叶水平的α-促黑素（α-MSH）释放可能产生的直接影响。研究了前列腺素对自发性和促甲状腺激素释放激素（TRH）刺激的α-MSH分泌的影响。未检测到前列腺素E1、前列腺素E2、前列腺素F1α或前列腺素F2α对α-MSH基础释放有显著影响。吲哚美辛未改变TRH诱导的α-MSH释放。相反，在存在1×10⁻⁶ M前列腺素E1的情况下，观察到TRH诱导的α-MSH分泌显著增加。对于1×10⁻⁸ M至1×10⁻⁶ M范围内的剂量，这种放大效应与TRH的浓度直接相关。
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