Tanabe T, Furuya H, Kanemoto N, Goto Y, Hata J
Tokai J Exp Clin Med. 1981 Jan;6(1):41-8.
To investigate the involvement of the immune mechanism in the development of pulmonary hypertension in rats given monocrotaline, pulmonary hypertension was induced in rats and the effect of daily injection of prednisolone was studied. Fifty six Sprague-Dawley rats (4 week-old males, 50-60 g) were divided into four groups as follows: (1) injection of monocrotaline alone (A: 17 rats), (2) injection of monocrotaline + long-term injection of prednisolone (B: 22 rats), (3) long-term injection of prednisolone (C: 7 rats) and, (4) long-term injection of physiological saline solution (D: 10 rats). The survival time was prolonged, and slightly better results in the pressure of the right ventricle, hypertrophy of the right ventricle and lesions of lung tissue were obtained in B than in A. However, the rise in the RV pressure the hypertrophy of the right ventricle in B were more pronounced than in C and D, and findings in the lung tissue closely resembled those of A. Judging from the above, it is certain that long-term injections of prednisolone improve the lung tissue lesions and prolong the life of monocrotaline induced pulmonary hypertensive rats. However, it is unlikely that the immune reaction plays a leading role in the development of pulmonary hypertension in the rats.
为了研究免疫机制在给予野百合碱的大鼠肺动脉高压发生过程中的作用，对大鼠诱导肺动脉高压，并研究每日注射泼尼松龙的效果。将56只Sprague-Dawley大鼠（4周龄雄性，体重50 - 60克）分为以下四组：（1）单独注射野百合碱（A组：17只大鼠），（2）注射野百合碱+长期注射泼尼松龙（B组：22只大鼠），（3）长期注射泼尼松龙（C组：7只大鼠），以及（4）长期注射生理盐水（D组：10只大鼠）。B组大鼠的存活时间延长，右心室压力、右心室肥厚及肺组织病变方面的结果略优于A组。然而，B组右心室压力升高和右心室肥厚比C组和D组更明显，且肺组织的表现与A组非常相似。综上所述，长期注射泼尼松龙确实能改善肺组织病变并延长野百合碱诱导的肺动脉高压大鼠的寿命。然而，免疫反应在大鼠肺动脉高压发生过程中不太可能起主导作用。
