Nowak J Z, Zandarowska E
Arch Immunol Ther Exp (Warsz). 1980;28(6):927-30.
Amodiaquine, 10(-5) M, totally inhibited the activity of histamine-methyltransferase (HMT) in the rat brain. Both peripheral (60 mg/kg i.p.) and central (50 and 100 microgram i.vt.) administration of the drug substantially reduced the HMT activity. Amodiaquine given i.p. or i.vt., in various doses, did not change the endogenous histamine (HI) level in the rat brain at any time studied (1-24 h). Amodiaquine (60 or 120 mg/kg i.p.) administered together with an inhibitor of diamine oxidase, i.e. aminoguanidine (either peripherally or centrally) had no effect on the endogenous HI content. Possible involvement of mechanisms other than methylation or oxidation in regulation of the endogenous HI level in the rat brain is discussed.
10⁻⁵ M的氨酚喹完全抑制了大鼠脑中组胺甲基转移酶（HMT）的活性。该药物经外周（腹腔注射60 mg/kg）和中枢（静脉注射50和100 μg）给药均能显著降低HMT活性。腹腔注射或静脉注射不同剂量的氨酚喹，在任何研究时间（1 - 24小时）均未改变大鼠脑内的内源性组胺（HI）水平。将氨酚喹（腹腔注射60或120 mg/kg）与二胺氧化酶抑制剂即氨基胍一起给药（外周或中枢给药），对脑内内源性HI含量没有影响。本文讨论了大鼠脑内内源性HI水平调节中除甲基化或氧化以外的其他机制的可能参与情况。
