Simmons M J, Johnson N A, Fahey T M, Nellett S M, Raymond J D
Genetics. 1980 Oct;96(2):479-80. doi: 10.1093/genetics/96.2.479.
The frequencies of sex-linked lethal mutations arising in hybrid male offspring from crosses and in nonhybrid controls were determined. The hybrids were produced by crossing representative strains of the P-M system of hybrid dysgenesis in all possible combinations. Males from the cross of P males x M females had a mutation rate about 15 times higher than that of nonhybrid males from the P strain. Genetically identical males from the reciprocal cross had a mutation rate 3 to 4 times that of the nonhybrids. For crosses involving a Q strain, a significant increase in the mutation rate was detected in males produced by matings of Q males with M females. No increase was observed in genetically identical males from the reciprocal mating. Crosses between P and Q strains gave male hybrids with mutation rates not different from those of nonhybrids. Many of the lethals that occurred in hybrids from the cross of P males x M females appeared to be unstable; fewer lethals that arose in hybrids from the cross of Q males x M females were unstable. The relationship between P and Q strains is discussed with respect to a model of mutation induction in dysgenic hybrids.
测定了杂交产生的杂种雄性后代以及非杂交对照中发生的性连锁致死突变的频率。杂种是通过将杂种不育P-M系统的代表性品系以所有可能的组合进行杂交产生的。P雄蝇与M雌蝇杂交产生的雄蝇的突变率比P品系的非杂交雄蝇高约15倍。来自反交的基因相同的雄蝇的突变率是非杂交雄蝇的3至4倍。对于涉及Q品系的杂交，在Q雄蝇与M雌蝇交配产生的雄蝇中检测到突变率显著增加。在反交产生的基因相同的雄蝇中未观察到增加。P品系和Q品系之间的杂交产生的雄性杂种的突变率与非杂种的突变率没有差异。在P雄蝇与M雌蝇杂交产生的杂种中出现的许多致死突变似乎是不稳定的；在Q雄蝇与M雌蝇杂交产生的杂种中出现的致死突变较少是不稳定的。关于发育不全杂种中突变诱导模型，讨论了P品系和Q品系之间的关系。
