Held K R
MMW Munch Med Wochenschr. 1981 Aug 7;123(32-33):1235-8.
Accidental pharmacotherapy in unrecognized pregnancy gives occasion for human genetic counseling to an increasing extent. In this, it must be clarified to what stage of development a drug was administered, whether a teratogenic effect is to be assumed, how long the effect lasts and whether compensation is possible for the damage which has occurred. Furthermore, genetic and non-genetic induced differences in the uptake, metabolization and excretion of drugs and the extent of the genetically induced sensitivity in special areas of the organ anlage in the embryo must be taken into account in the counseling.
未识别出怀孕时的意外药物治疗越来越多地引发了人类遗传咨询的需求。在此过程中，必须弄清楚药物是在发育的哪个阶段使用的，是否可认定有致畸作用，其作用持续多久，以及对已发生的损害是否有可能进行补偿。此外，在咨询过程中还必须考虑药物吸收、代谢和排泄方面的遗传和非遗传诱导差异，以及胚胎器官原基特定区域的遗传诱导敏感性程度。
