Licko V
NIDA Res Monogr. 1981;28:161-71.
Experimental data on 3H labelled naltrexone obtained from the Research Triangle Institute were analyzed. Both plasma and urine curves were resolved into their exponential components. Mean total clearance of unconjugated naltrexone was 3510 (300) ml/min, and its mean urinary clearance was 76.0 (6.8) ml/min. Fraction of dose excreted through urine was between 55 and 60%. Orally administered drug is completely absorbed into plasma. Plasma curve resulting from intravenous administration contained three exponentials: 1.9 (.5)/min, 0.18 (.07)/min and 0.00106 (.00008)/min. Distribution volumes were 7.6 (.7) liters, 60 (12) liters and 164 (16) liters. After oral administration there were two exponentials: 0.012 (.002/min and 0.00122 (.00009)/min. The faster exponential corresponds to gastrointestinal absorption with a half life of about 1 hour.
对从三角研究机构获得的3H标记纳曲酮的实验数据进行了分析。血浆和尿液曲线都被分解为各自的指数成分。未结合纳曲酮的平均总清除率为3510（300）ml/分钟，其平均尿液清除率为76.0（6.8）ml/分钟。经尿液排泄的剂量分数在55%至60%之间。口服给药的药物完全吸收进入血浆。静脉给药产生的血浆曲线包含三个指数成分：1.9（0.5）/分钟、0.18（0.07）/分钟和0.00106（0.00008）/分钟。分布容积分别为7.6（0.7）升、60（12）升和164（16）升。口服给药后有两个指数成分：0.012（0.002）/分钟和0.00122（0.00009）/分钟。较快的指数成分对应于胃肠道吸收，半衰期约为1小时。
