Reibel J F, McLean W C, Cantrell R W
Otolaryngol Head Neck Surg. 1981 May-Jun;89(3 Pt 1):398-401. doi: 10.1177/019459988108900308.
Only three examples of acinic cell carcinoma of the larynx or trachea are found in the recent literature. A case of acinic cell carcinoma of the subglottic larynx and trachea was diagnosed and treated at the University of Virginia Medical Center. To our knowledge this is the first such case with a prior history of radiation to the neck. The patient is a 56-year-old woman who was irradiated for hyperthyroidism 46 years ago. When seen she also had parathyroid hyperplasia and multiple thyroid adenomas, conditions that frequently follow irradiation of the thyroid in children. These findings in this case support the concept that radiation may be responsible for inducing this tumor, which otherwise rarely occurs in this location. The use of electron microscopy was extremely useful in the diagnosis of this tumor. She was treated with total laryngectomy and right neck dissection and is now free of disease one year after surgery.
近期文献中仅发现三例喉或气管的腺泡细胞癌。弗吉尼亚大学医学中心诊断并治疗了一例声门下喉和气管的腺泡细胞癌。据我们所知，这是首例有颈部放疗史的此类病例。患者为一名56岁女性，46年前因甲状腺功能亢进接受过放疗。就诊时她还患有甲状旁腺增生和多发性甲状腺腺瘤，这些情况在儿童甲状腺放疗后很常见。该病例的这些发现支持了辐射可能诱发此肿瘤的观点，否则该肿瘤在这个部位很少发生。电子显微镜的应用对该肿瘤的诊断极为有用。她接受了全喉切除术和右颈清扫术，术后一年目前无疾病。
