Endocrine mechanisms in the pathogenesis of essential hypertension. III. Special reference on the interrelations between the prostaglandin and kallikrein-kinin systems.

In the present paper, the involvement of the renal kallikrein-kinin system in the pathogenic mechanism of essential hypertension is discussed in the larger framework of the complex hormonal actions of prostaglandins (PGs), catecholamines, renin and angiotensins in the long-term control of arterial blood pressure and sodium metabolism. An attempt is also made to emphasize the role of the cerebral renin-angiotensin system in this pathogenic mechanism. To better understand the problems raised in this paper, the concomitant consultation of two previously published papers [88], [89] is recommended.