从女性和男性体内分离出的脂蛋白对前列环素合成酶活性的不同影响。

Differential influence of lipoproteins isolated from women and men on the activity of the PGI2 synthetase activity.

作者信息

Beitz J, Förster W

出版信息

Prostaglandins Med. 1981 May;6(5):515-8. doi: 10.1016/0161-4630(81)90110-5.

Abstract

We have found a correlation between the activity of the PGI2 synthetase in the microsomal fraction of pig aorta and the amount of high density lipoprotein (HDL) cholesterol in the incubation fluid. The reverse was true for low density lipoprotein (LDL) cholesterol. These correlations exist independently of whether the lipoproteins were isolated from men than from women as it is for HDL isolated from women than from men. This result may give an explanation for the differential risk against the incidence of cardiovascular disease between women and men at the same concentration of the individual lipoproteins in their blood.

摘要

我们发现猪主动脉微粒体部分中前列环素（PGI2）合成酶的活性与孵育液中高密度脂蛋白（HDL）胆固醇的含量之间存在相关性。低密度脂蛋白（LDL）胆固醇的情况则相反。这些相关性的存在与脂蛋白是从男性还是女性中分离出来无关，就如同从女性中分离出的HDL与从男性中分离出的HDL情况不同一样。这一结果可能为在血液中个体脂蛋白浓度相同的情况下，男性和女性患心血管疾病发病率的差异风险提供一种解释。