Vitali C, Bombardieri S, Spremolla G
Arch Intern Med. 1981 Sep;141(10):1349-51.
Eighteen months after the occurrence of Waldenström's macroglobulinemia, Philadelphia (Ph1) chromosome-positive chronic myeloid leukemia developed in a 69-year-old woman. The coexistence of the two disorders was characterized by an initial reduction of paraproteinemia at the time that leukemia occurred, a long-lasting remission of the two disorders, and a final parallel increase of paraproteins and WBCs. Since leukemia occurred 15 months after the interruption of melphalan therapy, the potential mutagenic role of chemotherapy was considered irrelevant. Therefore, Waldenström's macroglobulinemia might favor the occurrence of chronic myeloid leukemia.
在一名69岁女性发生瓦尔登斯特伦巨球蛋白血症18个月后，出现了费城（Ph1）染色体阳性的慢性粒细胞白血病。这两种疾病共存的特点是白血病发生时副蛋白血症最初减轻、两种疾病长期缓解以及最终副蛋白和白细胞平行增加。由于白血病在美法仑治疗中断15个月后发生，化疗的潜在致突变作用被认为不相关。因此，瓦尔登斯特伦巨球蛋白血症可能有利于慢性粒细胞白血病的发生。
