Zubairov D M, Soboleva I V, Vazhinskaia Z V, Chenborisova G Sh, Timerbaev V N
Biokhimiia. 1981 Jul;46(7):1210-4.
The role of protein moiety of tissue thromboplastin under its specific enzymatic modification and the effects of some protease inhibitors were studied. Treatment with HCl, pepsin and papain was followed by a decrease in the biological activity of thromboplastin, which was unaffected by the inhibitors of some proteolytic enzymes (DFP, monoiodoacetate and o-phenanthroline). It was assumed that the protein component of thromboplastin fulfils a structural function in the assembly of the lipoprotein matrix, on which surface the enzymatic reactions of blood coagulation are known to occur.
研究了组织凝血活酶蛋白质部分在其特定酶修饰下的作用以及一些蛋白酶抑制剂的影响。用盐酸、胃蛋白酶和木瓜蛋白酶处理后，凝血活酶的生物活性降低，而一些蛋白水解酶抑制剂（二异丙基氟磷酸、一碘乙酸和邻菲罗啉）对此无影响。据推测，凝血活酶的蛋白质成分在脂蛋白基质组装中起结构作用，已知血液凝固的酶促反应发生在该基质表面。
