Salner A L, Botnick L E, Herzog A G, Goldstein M A, Harris J R, Levene M B, Hellman S
Cancer Treat Rep. 1981 Sep-Oct;65(9-10):797-802.
Reversible brachial plexopathy has occurred in very low incidence in patients with breast carcinoma treated definitively with radiation therapy. Of 565 patients treated between January 1968 and December 1979 with moderate doses of supervoltage radiation therapy (average axillary dose of 5000 rad in 5 weeks), eight patients (1.4%) developed the characteristic symptoms at a median time of 4.5 months after radiation therapy. This syndrome consists of paresthesias in all patients, with weakness and pain less commonly seen. The symptom complex differs from other previously described brachial plexus syndromes, including paralytic brachial neuritis, radiation-induced injury, and carcinoma. A possible relationship to adjuvant chemotherapy exists, though the etiology is not well-understood. The cases described demonstrate temporal clustering. Resolution is always seen.
在接受根治性放射治疗的乳腺癌患者中，可逆性臂丛神经病变的发生率极低。1968年1月至1979年12月期间，565例患者接受了中等剂量的超高压放射治疗（5周内腋窝平均剂量为5000拉德），其中8例患者（1.4%）在放疗后中位时间4.5个月出现了特征性症状。该综合征在所有患者中均表现为感觉异常，较少见无力和疼痛。该症状复合体不同于先前描述的其他臂丛神经综合征，包括麻痹性臂神经炎、放射损伤和癌。尽管病因尚不清楚，但可能与辅助化疗有关。所描述的病例显示出时间上的聚集性。总能看到症状缓解。
