Reversibility of high-affinity binding of methotrexate in L1210 murine leukemia cells. - Suppr | 超能文献

Reversibility of high-affinity binding of methotrexate in L1210 murine leukemia cells.

作者信息

Cohen M, Bender R A, Donehower R, Myers C E, Chabner B A

出版信息

Cancer Res. 1978 Sep;38(9):2866-70.

Abstract

摘要

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Reversibility of high-affinity binding of methotrexate in L1210 murine leukemia cells.

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Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.叶酸类似物甲氨蝶呤在L1210白血病细胞中的载体介导转运

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Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.抗叶酸聚谷氨酸化及二氢叶酸还原酶处的竞争性药物置换作为L1210细胞中亚叶酸解救的重要因素。

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引用本文的文献

1

Growth kinetics of L1210 leukemic cells exposed to different concentration courses of methotrexate in vitro.

Cancer Chemother Pharmacol. 1994;34(4):351-5. doi: 10.1007/BF00686044.

2

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.甲氨蝶呤多聚谷氨酸在人乳腺癌细胞中的细胞内药代动力学。4-氨基-10-甲基蝶酰谷氨酸4和4-氨基-10-甲基蝶酰谷氨酸5对二氢叶酸还原酶的选择性保留及较少的解离性结合。

J Clin Invest. 1983 Sep;72(3):773-8. doi: 10.1172/JCI111048.

3

Methotrexate polyglutamate synthesis by cultured human breast cancer cells.培养的人乳腺癌细胞中甲氨蝶呤多聚谷氨酸的合成

Proc Natl Acad Sci U S A. 1980 May;77(5):2919-22. doi: 10.1073/pnas.77.5.2919.

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Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.人小细胞肺癌细胞系对甲氨蝶呤敏感性的决定因素。

J Clin Invest. 1985 Oct;76(4):1323-9. doi: 10.1172/JCI112106.